Various chemotherapeutic agents like doxorubicin, paclitaxel, imatinib, dasatinib, nilotinib, gefitinib, erlotinib, and bortezomib regulate Bim expression and its signaling to the execution apoptotic cell death in breast cancer, colon cancer, lung cancer, and leukemia [21,32]. This evidence concerns the gene BCL2L11 and colonic neoplasm.