CASP8 and osteosarcoma: The analysis of transcript levels determined for genes associated with apoptosis revealed that the apoptosis process noted in osteosarcoma cell lines may depend on various factors, however in all osteosarcoma cell lines we noted increased mRNA level for caspase 8 (Casp8) which confirms studies published by Seki et al. who revealed that Casp8 is a key molecule in the earliest stage of apoptosis induced by cisplatin in human osteosarcoma cells (HOS).