In addition, polymorphisms in GCH1 that were originally identified as risk factors in persistent lumbar root pain (Tegeder et al., 2006) have been associated with NeuP in a further two different etiologies (HIV-induced sensory neuropathy and persistent postsurgical pain) suggesting that the recently discovered role of GCH1 in energy metabolism may potentially lie at a key intersection in NeuP development (Cronin et al., 2018). This evidence concerns the gene GCH1 and Sensory neuropathy.