KEAP1 and myocardial ischemia: In response to oxidative stress, Nrf2 dissociates from the Keap1 protein and migrates to the cell nucleus, where it stimulates the production of antioxidant enzymes.39 Myocardial ischemia promotes increased protein expression of Nrf240 and the effect of açaí on Nrf2 expression was verified in an astrocyte culture study in which the fruit reduced the protein expression of Nrf2.41 However, in another study, also with astrocyte culture, açaí administration increased Nrf2 expression,36 showing that the effects of açaí on Nrf2 are not completely understood.