PLK1 and neoplasm: Based on the fact that Plk1 is required for mitotic entry during recovery from G2 arrest induced by DNA damage [60], and based on our preliminary data in which Plk1 is a functional key gene in the basal-like cell line SUM149, we demonstrated that Plk1 inhibition synergized with chemotherapies such as taxane, specifically inhibiting the G2-M transition, inducing aberrant mitotic exit, and apoptosis and the elimination of stem cell-like resistant tumor clones.