Based on known susceptibility to RVFV MP-12 strain [43–46], we used three different human cells: MRC-5 cells (human lung diploid cells: type-I IFN-competent), A549 cells (human lung adenocarcinoma cell line: type-I IFN-competent), and Hec1B cells (human endometrial adenocarcinoma cell line: deficient in the early IFN signaling pathway via IFN-AR1 [47, 48]), and two different mouse cells: MEF cells (mouse embryonic fibroblast cells: type-I IFN-competent) and Hepa1-6 cells (murine hepatoma cell line: type-I IFN-competent). Here, IFNAR1 is linked to hepatocellular carcinoma.