GBA1 and Atrophy: Shuffling the transcription profile of either gene significantly degraded model fit (Fig 6A, GBA: p25% = 0.0031, p30% < 0.001, p35% < 0.001, p40% < 0.0024; Fig 6B, SNCA: p25% = 0.0102, p30% = 0.0201, p35% = 0.0084, p40% = 0.0334), suggesting a significant role of GBA and SNCA expression in driving the spatial patterning of atrophy.