After controlling for the other variables that were also associated with this complication in the univariate analyses, namely, male gender (yes/no), diabetes duration (years), smoking history (positive/negative), BMI (kg/m2), insulin use (yes/no), eGFR (mL/min/1.73 m2) and total cholesterol (mmol/L), the A allele remained significantly associated with DR in the final model (Table 3). The gene discussed is INS; the disease is diabetes mellitus.