Furthermore, elevated levels of HSP90 and HSP70, and glucose-related protein 78 (GRP78), in medullary thyroid carcinoma revealed their potential role in medullary thyroid carcinoma tumor biology, suggesting that they could be developed as biomarkers in the future (Soudry et al., 2017). This evidence concerns the gene HSPA5 and medullary thyroid gland carcinoma.