NLRP3 and Infertility: Given the parallels of ovulation with inflammatory processes and the correlation of non-steroidal anti-inflammatory drug use with reversible infertility (Akil et al., 1996; Mendonça et al., 2000; Duffy et al., 2019), the present study therefore utilized animal model to examine that expression and localization of NLRP3 inflammasome through immunohistochemistry and Western blotting during the follicular development induced by PMSG for help to further clarify the ovulatory mechanism in mammals.