NLRP3 and Infertility: Furthermore, the correlation between non-steroidal anti-inflammatory drug use and reversible infertility in women indicated the ovulatory processes with inflammatory responses (Akil et al., 1996; Mendonça et al., 2000; Duffy et al., 2019), further implying the activation of NLRP3 inflammasomes may play an important role in the regulation of ovarian ovulation in mammals.