However, in the AD brain, Tau undergoes abnormal post-translational modifications that render it prone to self-assemble and form β-sheet rich amyloidogenic deposits such as Paired Helical Filaments (PHFs) and Neurofibrillary Tangles (NFTs) that eventually lead to neuronal death (Alonso et al., 2001; Barghorn et al., 2004; Kolarova et al., 2012). This evidence concerns the gene MAPT and Alzheimer disease.