STAT3 and neoplasm: Furthermore, significant correlations were found between higher Tyr705-phosphorylated STAT3 expression and higher tumor size (p = 0.048), poorer differentiation (p < 0.000), higher clinical stage (p = 0.002), and the presence of lymph node metastasis (p = 0.010), while no obvious relations were found between Tyr705-phosphorylated STAT3 and age, gender, drink, smoke, and recurrence in this study (Table 2).