MSS s-CRC shows also specific up-regulation of a series of other APB-genes (MRE11A, RAD50, SMC6, and NSMCE2), and down-regulation of SP100, which has an inhibitory effect on ALT through sequestration of the MRN complex (NBN, RAD50, MRE11A) from APBs (Figure 6) (79, 80). The gene discussed is NSMCE2; the disease is colorectal carcinoma.