Activating genes in this branch, first of all TERT, heat shock protein 90 (HSP90AA1, HSP90AB1), importin 7 (IPO7) and p23 (PTGES3) are overexpressed in cancer, while the heat shock protein 70 (HSPA1A) and CHIP ubiquitin ligase (STUB1), both acting as suppressors, are underexpressed (Figure 5). This evidence concerns the gene PTGES3 and cancer.