SP100 and colorectal carcinoma: Indeed, 34% (LS-CRC) and 79% (s-CRC) of all 67 TMM genes in the TEL and ALT-pathways show significant up-regulation (adjusted p <0.05), while only three genes (RBM7, SP100, and RAD52) get significantly down-regulated in at least one of the subtypes (Figure 6, Supplementary Figure 9).