Mutations of ATRX and of TERT are not sufficient as possible indications for ALT- and TEL-TMM because loss of ATRX coexist with TEL-TMM in some cell lines (15) and melanomas, which can show ATRX and TERT mutations in parallel (16), while they are mutually exclusive in in glioma (17). This evidence concerns the gene TERT and central nervous system cancer.