More detailed inspection revealed pronounced differences between MSS and MSI s-CRC: most of the genes having high BC values in MSS s-CRC belong to the TEL pathway (e.g., TERT and DKC1), including also the TEL-sink node while the tail of the distribution showing low BC values accumulates ALT genes (Figure 8B). The gene discussed is TERT; the disease is colorectal carcinoma.