IPO7 and cancer: Activating genes in this branch, first of all TERT, heat shock protein 90 (HSP90AA1, HSP90AB1), importin 7 (IPO7) and p23 (PTGES3) are overexpressed in cancer, while the heat shock protein 70 (HSPA1A) and CHIP ubiquitin ligase (STUB1), both acting as suppressors, are underexpressed (Figure 5).