MSS s-CRC shows also specific up-regulation of a series of other APB-genes (MRE11A, RAD50, SMC6, and NSMCE2), and down-regulation of SP100, which has an inhibitory effect on ALT through sequestration of the MRN complex (NBN, RAD50, MRE11A) from APBs (Figure 6) (79, 80). This evidence concerns the gene NBN and colorectal carcinoma.