In addition, miR-199a-5p could cooperate with let-7c and increase sorafenib sensitivity of HCC cells by directly targeting MAP4K3 (MEKKK3, MAPKKKK3), which then regulates MAP4K3 expression, together playing an important role in inhibiting migration, invasion and metastasis of HCC cells (22). This evidence concerns the gene MAP4K3 and hepatocellular carcinoma.