For instance, the expression of miR-142-3p significantly decreases in HCC cells after exposure to sorafenib, while miR-142-3p overexpression results in a remarkable weakening in the expression of ATG5 and autophagy-related 16-like 1 (ATG16L1) and re-sensitive HCC cells to sorafenib (33). This evidence concerns the gene ATG5 and hepatocellular carcinoma.