However, inhibition of the PD-1/PD-L1 axis was shown to reinforce the NK activity in multiple myeloma (105, 107, 117), and in a pre-clinical melanoma model, the up-regulation of PD-L1 by tumor-infiltrating and tumor-draining lymph nodes resulted in decreased PD-1+ DC cross-priming activity (118). Here, CD274 is linked to melanoma.