IL6 and melanoma: Furthermore, other immune modulatory effects induced by these therapies include the impairment of MDSCs and Tregs activity, the reduced production of IL-10, IL-6, and VEGF by melanoma cells in TME as well as the down-modulation of the C-C chemokine ligand (CCL)-2 that is mostly involved in macrophage recruitment and survival (106, 139, 140).