MIF and autoimmune disease: In addition, apart from being rich in TGF-β, other studies have demonstrated that the aqueous humor contains large amounts of the pleiotropic cytokine Macrophage Migration Inhibitory Factor (MIF), which promotes immune privilege by inhibiting NK cell activity (24), though MIF possesses proinflammatory properties that qualify it as an important mediator of several autoimmune diseases such as multiple sclerosis and Guillain Barrè syndrome (25, 26).