PROM1 and glioblastoma: Our recent studies demonstrate by using qRT-PCR that although no statistically significant difference exists between the mRNA expression level of LIS1 gene in glioblastoma compared with normal brain tissue, a spectacular difference (expression of up to 60-fold higher) was found between LIS1 mRNA expression in CD133+ compared to CD133- primary glioblastoma cells (13, 14).