ACSS2 and neoplasm: Our previous study revealed that AMP-activated protein kinase (AMPK) can mediate ACSS2 phosphorylation at S659 (ACSS2 pS659) to induce its nuclear translocation in a glucose-deficient environment, and the binding of ACSS2 to the promoter regions of lysosomal and autophagy genes can promote acetyl-CoA production to support histone acetylation and gene expression to promote tumor development (16).