We recently reported that a splicing switch from KHK-C to KHK-A occurs in hepatocellular carcinoma (HCC), leading to fructose metabolism reduction, and KHK-A phosphorylates and activates phosphoribosyl pyrophosphate synthetase 1 (PRPS1), resulting in increased de novo nucleic acid synthesis for HCC development (6). Here, PRPS1 is linked to hepatocellular carcinoma.