With respect to their close interactions with miRNAs, circRNAs exert great effect on modulating progression of malignancies and takes part in different signaling pathways in cancers like mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) intracellular pathway and Wnt/β-catenin pathway (26). Here, AKT1 is linked to cancer.