These results indicated Act D suppresses tumor growth through RNase L. Moreover, we used Ki-67 to evaluate the proliferation of tumor cells and found that Act D could suppress the proliferation in RNase L-high expressed or RNase L-overexpressed samples (Figures 5D,E,G,H), while Act D showed limited effects in RNase L-low expressed or RNase L-knockdown samples (Figures 5D,E,G,H). Here, RNASEL is linked to neoplasm.