ESR (<0.001), CRP (0.03), IgM (0.004)ESSPRI (p=0.87), ESSDAI (p=0.63), cardinal signs (pain, fatigue, dryness) evaluated by practitioner (p=0.76), systemic signs evaluated by practitioner (p=0.49), SF-36, physical health component (p=0.85), SF-36, mental health component (p=0.23), HAD-anxiety (p=0.54), HAD-depression (p=0.26), Schirmer test (p=0.42), uSF, mL/min (p=0.45), serum IgG, g/L (p=0.13), serum IgA, g/L (p=0.85). The gene discussed is CRP; the disease is depressive symptom measurement.