In another study in four glioblastoma cell lines, cytotoxicity of the bioreductive antitumor agents, mitomycin C (MMC) and streptonigrin (SN), in presence or absence of DMF as inducer of DT-diaphorase (DTD) (i.e., an obligate two-electron reductase that bioactivates chemotherapeutic quinines) was compared with the 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) as a usual chemotherapeutic agent. The gene discussed is NQO1; the disease is glioblastoma.