Effective genes in lipid metabolism such as paraoxonase/arylesterase 1 (PON1), cholesteryl ester transfer protein (CETP), apolipoprotein E (APOE), and 5-lipoxygenase activating protein (ALOX5AP) are subjects of recent studies about stroke.8,9 Among these genes, ALOX5AP has received the most attention. The gene discussed is APOE; the disease is Stroke.