Higher haptoglobin levels were linked with an increased risk of colorectal cancer death (49).Serum HP is associated with poor prognosis of CRC patients and that HP promotes colorectal cancer cell invasion (50).Combination of haptoglobin and osteopontin could predict colorectal cancer hepatic metastasis (51).Distinctive expression pattern of HP in breast, colorectal and lung cancer (52). This evidence concerns the gene SPP1 and colorectal cancer.