Plasma ORM2 is an independent prognostic factor both for overall and for cancer-specific survival in patients with stage II CRC (78).ORM2 could be used as a potential biomarker in the diagnosis of CRC (79).Overexpression of Plasma ORM2 could serve as a new risk marker for Cholangiocarcinoma (CCA) (80-82).ORM1 and ORM2 plasma concentrations are increased in breast, lung, and ovary cancers (83). This evidence concerns the gene ORM2 and cholangiocarcinoma.