Patients with CRC exhibited significantly increased APOA1 levels after adjuvant chemotherapy (62).The higher amounts of APOA1 reduce breast, colorectal, and lung cancer risk (63).ApoA1 is inversely associated with lung cancer risk (64).ApoA1 is closely related to breast cancer (65).ApoA1 as a biomarker for diagnosis of Pancreatic carcinoma (PC) (66). Here, APOA1 is linked to pachyonychia congenita.