Results showed that the expression levels of HPR (haptoglobin-related protein), HP (haptoglobin), ALB (Serum albumin), KRT1 (Keratin, type II cytoskeletal 1), APOA1 (Apolipoprotein A-1), FGB (Fibrinogen beta chain), IGJ (Immunoglobulin J chain) and C4A (Complement C4-A) were lower in advanced polyp sample compared to normal one and as well as, they were lower in cancer sample rather than polyp one. The gene discussed is JCHAIN; the disease is polyp.