Metastatic colon cancer show relatively small decline of ALB compared to the mean in tumor-free patients (53).The preoperative CRP/ALB ratio is a useful prognostic marker in patients with colorectal and ovarian cancer who undergo potentially curative surgery (54-57).Alb is an important prognostic factor for patients with Hepatocellular carcinoma (HCC) (58). The gene discussed is ALB; the disease is malignant colon neoplasm.