Immunohistochemical staining confirmed the absence of haptoglobin in normal colon and the ectopic expression of haptoglobin in colon cancers and adenomatous polyps (47).HPR in laryngocarcinoma patients were downregulated (48).HPR -epitope expression is a clinically important predictor of the recurrence of cancer in patients with early breast cancer, especially in combination with progesterone-receptor status (43). The gene discussed is HP; the disease is breast cancer.