ORM2 and colorectal carcinoma: Whereas, ORM2 was a good factor for further confirmation of expression changes, because it was up-regulated in CRC samples and can be an excellent diagnostic biomarker, but since it has already been validated with Enzyme-Linked Immunosorbent Assay (ELISA) and Western blot in other studies (78, 79), we gave up to reconfirm this protein.