FGB has prognostic value for lung adenocarcinoma (67).FGB in combination with other four urinary biomarkers not only discriminates lung cancer patients from control groups but also differentiates lung cancer from other common tumors (68).Elevated plasma fibrinogen levels and tumor progression in patients with gastric cancer have been largely reported (69).Increased expression of FGB was correlated with increased bladder tumor stage and can be a potential diagnostic marker (70). This evidence concerns the gene FGB and lung cancer.