TGFB1 and Cirrhosis: Transforming growth factor-β (TGF-β) is a key regulator of fibrosis (Meng et al., 2016) and is strongly involved in chronic liver disease contributing to all stages of disease progression from initial liver injury to fibrosis, cirrhosis, and hepato-cellular carcinoma (Dooley and ten Dijke, 2012; Fabregat et al., 2016).