EGFR and lung adenocarcinoma: Besides this, we made a profound analysis of the 3,243 tumors data of lung adenocarcinoma patients in China, then three EGFR mutations (V742I, I789M, N842H) related with erlotinib, gefitinib, lapatinib, and one EGFR mutation (S811C) related with afatinib were discovered by filtered in Hotspot3D results.