In the current study, we have identified differentially expressed genes (DEGs) from various stages of disease and found that most of the DEGs relative to normal vs. TB disease condition (including latent infection) are enriched in important pathway like-toll like receptor, NOD-like receptor signaling pathway, MAPK signaling pathway, TNF signaling, chemokine signaling pathway, PI3K-Akt signaling pathway, apoptosis etc. In fact, pathogen is identified by the receptors on the surface of immune cells, and toll-like receptors (TLRs) are one of them. This evidence concerns the gene TNF and disease arising from reactivation of latent virus.