While in normal to active TB, we found 15 genes out of which eight genes (EIF2AK2, SAMD9L, IFI44L, DDX58, IFI44, HERC5, NFE2L3, LRRK2) were up-regulated, and seven genes (CSF3, MAP3K8, IRAK2, TNFAIP3, TRAF1, PLAUR, and CD44) were down-regulated, and similarly, for latent to active TB diseases, three genes (TST, MTHFD1, CARS2) were up-regulated, and five genes (ETV6, NFKB1, MET, DOCK4, PARD6G) were down-regulated. The gene discussed is HERC5; the disease is tuberculosis.