Although, more studies need to be conducted to understand better the pathomechanisms involved in refractory anaphylaxis, we propose to increase the use of second-line medication such as methylene blue, vasopressin and (in suspicion of a beta-adrenergic blockade) glucagon in cases where 2 doses of adrenaline did not result in a rapid normalization of anaphylaxis symptoms. Here, GCG is linked to anaphylaxis.