MME and hydrops fetalis: Even though the total amount of natriuretic peptides in these patients is lower than in HFrEF, this inhibitor of the neprilysin system is being investigated in HFpEF in the PARAGON HF trial, after data collected from the exploratory phase II PARAMOUNT study pointed toward a reduction in the total amount of natriuretic peptides with an improvement in NYHA class end renal function.