Necroptosis mediates ODC degeneration induced by TNF-α, whose binding to TNFR1 triggers caspase-8 activation, and the inhibition of RIPK1 protects against ODC cell death in two animal models to study MS, and also in cell culture (Ofengeim et al., 2015). The gene discussed is CASP8; the disease is myeloid sarcoma.