Considering the multiple signaling GSK-3β involved and the wide distribution of GSK-3β, it is possible that this synaptic function of SHANK3B may also be important for the pathology of many other neuropsychiatric and neurodevelopmental disorders, such as Alzheimer’s disease and Schizophrenia. The gene discussed is GSK3B; the disease is early-onset autosomal dominant Alzheimer disease.