Finally, proto-oncogene pleomorphic adenoma gene-like 2 (PLAGL2) has been implicated in a variety of cancers, including leukemia, gastrointestinal, colon, lung, and prostate (Yang et al., 2011; Hanks and Gauss, 2012; Liu et al., 2014; Guo et al., 2016). This evidence concerns the gene PLAGL2 and cancer.