ANXA1 and melanoma: For example, Annexin A1 (encoded by ANXA1) is a Ca(2+)-regulated phospholipid-binding protein that is overexpressed in many cancers such as breast, pancreatic, and melanoma (Boudhraa et al., 2014; Belvedere et al., 2016; Shin et al., 2016), having many roles in the progression of this disease by localizing to different cell compartments (Boudhraa et al., 2016).