PLAG1, a PLAG gene family member that is very closely related to PLAGL2 both structurally and functionally (Van Dyck et al., 2007) is a transcription factor that has been associated to single-nucleotide polymorphisms (SNPs) identified in a genome-wide association study using AD databases (Liu et al., 2018). Here, PLAG1 is linked to Alzheimer disease.