We found that most of the pathways were down regulated including ILK signaling, neuroinflammation signaling, dendritic cell maturation, PKC signaling in T cells, NFAT regulation, NF-kB activation, Th1 pathway, PD-1, PD-L1 cancer immunotherapy whereas endocannabinoid cancer inhibitory pathway and interferon signaling were upregulated in TG_EE-vs-TG_SE compared with WT_EE-vs-WT_SE or TG_SE-vs-WT_SE conditions (Figure 6B). Here, CD274 is linked to cancer.