The SNAG domain of SNAI2 functions as a molecular hook to recruit LSD1 to the promoters of its target gene, such as CDH1, decreases the monomethylation and dimethylation of histone H3 lysine4 (H3K4) at this region, downregulates gene expression, and consequently contributes to cancer metastasis [47, 48]. The gene discussed is KDM1A; the disease is cancer.