Indeed, both PPAR‐γ and Smad‐7 have been displayed the capability of reducing atrial fibrosis and AF vulnerability,37, 39 and our data strongly favour that CYP2J2/EET suppresses atrial fibrosis by modulating atrial fibroblasts activation via PPAR‐γ/Smad‐7. Here, CYP2J2 is linked to atrial fibrillation.