Besides that, emerging evidence indicated enhanced inflammatory responses in patients with AF and accompanied by increased circulating levels of pro‐inflammatory cytokines.5, 6 Further, NLRP3 inflammasome activation was recently shown to be involved in the pathogenesis of AF.7 Because AF is able to exacerbate inflammation and atrial fibrosis that further perpetuates the arrhythmia, reduction of inflammation and reversal of structural remodelling have increasingly become the focus of new therapeutic strategies for the prevention of AF.3, 6. Here, NLRP3 is linked to atrial fibrillation.