CYP2J2 and atrial fibrillation: Here, we found that abdominal aortic constriction (AAC) operation enhanced the atrial fibrosis and inflammation response, resulting in increased AF occurrence and AF duration, whereas cardiac‐specific overexpression of CYP2J2 via adeno‐associated virus 9 (AAV9) vector reduced the susceptibility of AF, as well as ameliorated atrial fibrosis and inflammation in mice with AAC.