HFD in mice induced acute reduction of glucose transporter 1 (GLUT1), which was then gradually restored upon prolonged HFD in parallel with compensatory upregulation of vascular endothelial growth factor (VEGF) by CD206+ macrophages at the BBB.64 Myeloid‐specific deletion of VEGF (VEGFalox/lox LysM Cre+/‐) impaired BBB‐GLUT1 expression, brain glucose uptake, and memory formation in obese mice, as well as exacerbated neuroinflammation and cognitive decline in APP‐PS1 mice. Here, VEGFA is linked to Mental deterioration.