Adjusted to all influential variables (age of diagnosis, grading, tumor size, nodal status, lymphatic invasion, venous invasion, HER2 status) in a multivariable Cox regression model, the better OS in the CHT group was still evident (HR 0.494, 95% CI 0.343–0.711, p < 0.001, Table 3). This evidence concerns the gene ERBB2 and neoplasm.