Biologically, FBXW2 promotes tumor sphere formation by upreglating SOX2 via inducing MSX2 degradation, while MLN4924 sensitizes breast cancer cells to tamoxifen by depleting SOX2 via targeting the FBXW2-MSX2 axis (Yin et al., 2019). The gene discussed is FBXW2; the disease is breast carcinoma.