BRAF and neoplasm: The tumor decreased by more than 25% after BRAF MEKi was started (Fig. 4a) but unfortunately increased after a drug holiday (Fig. 4c), and continued to grow despite re-starting therapy with BRAF MEKi (Fig. 4d), at which point the autophagy inhibitor chloroquine was added halting the rate of tumor progression and even causing a slight decrease in the lesion size (Fig. 4e).