HDC and neoplasm: In agreement with the present results, in a murine lymphoma model developed with EL-4 cells, histamine treatment reduced tumour growth while it induced intratumoural accumulation of maturated dendritic cells.49 In addition, enhanced inflammation and higher tumour burden at mucosal sites (intestine and skin) were shown in models of chemically induced carcinogenesis developed in HDC knockout mice compared with wild-type animals.