Furthermore, since DTX-resistant PCa cells had elevated TR4 expression (See Fig. 2c), we treated parental and DTX-resistant 22RV-1 and C4-2 cells with Bex, and found that 8 μM Bex could reduce cell proliferation in DTX-resistant cells, but had no significant change in parental cells (Fig. 3d). Here, NR2C2 is linked to posterior cortical atrophy.