HIF1A and central nervous system cancer: In hypoxic hepatocellular and glioma tumor cells, knocking down lincRNA-p21 could enhance radio-sensitivity through HIF-1/Akt/mTOR/P70S6K signaling [32], while in human colorectal cancer, lincRNA-p21 enhanced the sensitivity of radiotherapy by targeting the Wnt/β-catenin signaling [33].