For the mice engrafted with the DLBCL PDX models, we examined five models with or without MYC and BCL2 molecular re-arrangements: DFBL-74251 (BCL2 rearrangement only), DFBL-75549 and DFBL-96117 (MYC rearrangement only), and DFBL-69487 and DFBL-20954 (MYC/BCL2 double-hit). The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.