In our previous paper, we reported an abnormal leptin bioavailability with increased levels of the soluble leptin receptor (sOB-R) in AIS girls15, which was associated with suboptimal bone qualities including lower volumetric BMD in cortical bone and abnormal trabecular bone micro-architecture attributable to impaired osteoblast activities16,17. The gene discussed is LEP; the disease is androgen insensitivity syndrome.