However, several sgRNAs were only identified in the nude mice allograft screen, including sgRNAs targeting Mup14, Zbtb14, Artn, Atm, Fbxw7 and Slc9a3. Interestingly, FBXW7 and SLC9A3, including several other candidates from the screen in nude mice, were identified as being prone to co-mutation with KRAS in the TCGA data set of all human cancers (Table S1). The gene discussed is FBXW7; the disease is cancer.