ITGAM and acute myeloid leukemia: However, Supplementary Fig. S3A,B show that although the BM from mouse #M4352 is almost completely replaced by Mac1+/Gr1+ leukemic cells, it is negative for a clonal Tcrb-DJ rearrangement, whereas the thymus, less infiltrated with Mac1+/Gr1+ AML is positive for a clonal Tcrb-DJ rearrangement.