ITGAM and acute myeloid leukemia: However, a prominent invasion of Mac1+/Gr1+ cells was observed in the thymus of double transgenic mice (Fig. 1c); in many cases, the invasion was more prominent in the thymus than BM (Fig. 1c and Supplementary Table S1), leading to the intriguing possibility that the AML in the NP23/NHD13 mice was derived from thymic-resident cells rather than BM-resident cells.