In our study, levels of several immune markers, such as IFN-α, IL-12, IL-6, IL-17, IL-10, IL-5, IL-2R, ST2/IL-1R4, CCL2, CCL3, CXCL9, M-CSF and E-Selectin, were significantly higher in presymptomatic/asymptomatic ZIKV infection (A-ZIKV group) when compared to the NI control group. This evidence concerns the gene IL1RL1 and Zika virus infectious disease.