The gp120-tg mouse model for HIV-induced neurotoxicity is not ideal for modeling HIV infection of the brain, but it does present many of the neuropathological features found in postmortem HIV+ brain tissues41,42,44,89, along with some aspects of cognitive impairment (d’Hooge et al. 1999; Maung et al. 2014) that were reflected in the failure to improve rotarod performance by these mice in the present study. This evidence concerns the gene ITIH4 and Cognitive impairment.