Distinct from the causal genetic variants in PD, many of the hub genes identified in our PD network have not been reported to be genetically linked to the disease, including our top hub gene of interest, STMN2. However, these key hub genes are predicted and/or confirmed to govern the expressions of many other genes, including disease-associated GWAS genes in the disease-specific networks and therefore are considered as drivers that can modify disease onset and progression. This evidence concerns the gene STMN2 and Parkinson disease.