Specifically, knockdown of Stmn2 upregulated nine PD GWAS genes (GPNMB, SREBF1, STAB1, LHFPL2, PRRG4, CTSB, FNDC3B, PPFIBP1, and COL5A2), and downregulated one PD GWAS gene (SYT4) at the mRNA level. The gene discussed is STAB1; the disease is Parkinson disease.