For example, our previous study integrated large-scale genetic and gene expression data as well as clinical and pathological traits into multiscale network models of Alzheimer’s disease (AD)16, and several predicted key regulators of AD pathogenesis such as TYROBP, DTL/CDT2, and GJA1 were subsequently validated in various model systems24–27. The gene discussed is DTL; the disease is early-onset autosomal dominant Alzheimer disease.