MAPT and Parkinson disease: Overexpression of Tau downregulated Stmn2 in PC12 cell line58; administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) also caused downregulation of Stmn2 level and the rescue of MPTP-induced PD-like phenotype restored Stmn2 expression in mice59, implicating a potential association between Stmn2 and PD.