We chose 15 genes, eight components of the spliceosome selected from the functional analysis using KEGG database (SRSF1, SRSF3, SF3B1, DDX42, DHX15, HNRNPU, THOC1, and U2SURP), and seven genes from the list of the 40 most deregulated genes, whose role in cancer is less well understood (WARS, AHR, DUSP5, CD79A, GADD45A, GADD45B, and PDE4B). The gene discussed is PDE4B; the disease is cancer.