Excluding genes without known specific functions (CDC27 and TNRC18), ARID2, HEBP1, LTBP1, and PLVAP were the only significant differences in the cancer group revealed by the gene-score methodology, while DFFA, FAM193A, and VEGFA were the only significant differences in the osteoporosis group. This evidence concerns the gene HEBP1 and osteoporosis.